HD-SCA HIGH-DEFINITION SINGLE CELL ANALYSIS TO CHARACTERIZE CANCER

Click here for a presentation describing the HD-SCA method. Please contact us (kolatkar at usc dot edu) if you have trouble accessing any of the content.

HD-SCA and Anatomical Pathology: Development of the assay as reported in
Marrinucci et al. Phys Biol 2012.
This dataset is large so please be patient while it loads.
Click for Pivot


HD-SCA and single-cell genomics:tracing therapy response in a prostate cancer patient reported in
Dago et al. PLoS ONE 2014.
Click for Pivot


HD-SCA data from a Breast cancer patient cohort.
Click for Pivot


HD-SCA and single-cell genomics: tracing disease evolution in a breast cancer patient.
Click for Pivot


HD-SCA and single-cell genomics: limited heterogeneity in a melanoma patient as reported in
Ruiz et al. Phys Biol 2015.
Click for Pivot


HD-SCA data for a metastatic castrate-resistant prostate cancer cohort undergoing a cabazitaxel ± carboplatin clinical trial (MD Anderson prostate cancer).
Click for Pivot


CTC and DTC data from a cohort with low- to high-risk, localized prostate cancer (Johns Hopkins Hospital prostate cancer).
Click for Pivot


HD-SCA data from a phase III randomized placebo-controlled trial in post-menopausal patients with hormone-receptor positive stage IV breast cancer
(S1222 breast cancer).
Click for Pivot


High-Definition Single-Cell Assay (HD-SCA) analysis produces both image and numerical data. It can be difficult to filter through the diverse data types to find data fitting specific parameters. Towards that end, we have developed a graphical web-based approach to enable researchers to quickly obtain a subset of image and associated assay data based on the filters chosen. Pivot, a Microsoft application, is used to provide a graphical interface that enable non-computer savvy users to quickly find the data they want.
Click on the links below to start the application (please be patient as it may take 120 seconds or so to load the first time). The pane along the left-hand side displays the parameters that are used to filter the data. The large area in the middle displays images of cells that meet the criteria chosen from the left-hand panel. Clicking on a single image in the center pane will zoom in on that cell and display additional information for the chosen cell in the right-hand pane.